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KMID : 1161420140170111247
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Journal of Medicinal Food
2014 Volume.17 No. 11 p.1247 ~ p.1255
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Agave Fructans: Their Effect on Mineral Absorption and Bone Mineral Content
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Garcia-Vieyra Maria Isabel
Del Real Alicia
Lopez Mercedes G.
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Abstract
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In this study we investigate the effect that Agave fructans as new prebiotics have on mineral absorption improvement. Forty-eight 12-week-old C57BL/6J mice were used in this study. Forty mice were ovariectomized and eight were sham-operated controls. Mice were fed standard diets or diets supplemented with 10% Agave fructans or 10% inulin fructans. Calcium and magnesium were evaluated as well as their excretion in feces. Osteocalcin levels were also measured; femur structure was studied by scanning electron microscopy. Other parameters, such as food intake, body weight, glucose, and short-chain fatty acid content, were recorded. Calcium in plasma and bone increased in Agave fructan groups (from 53.1 to 56 and 85?mg/L and from 0.402 to 0.474 and 0.478?g/g, respectively) and osteocalcin increased in all fructan groups (>50%). Scanning electron microscopy showed that fructans were able to mitigate bone loss. In conclusion, we demonstrated that supplementation with Agave fructans prevents bone loss and improves bone formation.
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KEYWORD
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calcium, functional foods, osteocalcin, osteoporosis, prebiotics
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